Nanjing Chemical Material Corp.
Service
Products

Production and Function of Monoammonium Glycyrrhizinate Production and Function of Monoammonium Glycyrrhizinate

Monoammonium glycyrrhizinate in China is a chemical substance. This product is mainly used for the treatment of chronic persistent hepatitis, chronic active hepatitis, liver poisoning, and early liver cirrhosis.

Production method
It is obtained by using crude glycyrrhizic acid (content about 50%, weight method) as raw material and acidic ethanol as extractant. 50g crude glycyrrhizic acid was added to 170ml of 95% ethanol acidified with hydrochloric acid (Ph value 3.5 ~ 4.0), and stirred and extracted at 40 ~ 50 ℃ for 4h. After filtration, the filter residue was extracted with 100 ml of ethanol under the same conditions for 3 hours. The extracts were combined, and ammonia water or ammonia gas was added dropwise with stirring to make the Ph of the solution 7.2 to 7.5, and allowed to stand at room temperature for 0.5 h to completely precipitate.

The precipitate is triammonium glycyrrhizinate, which is dispersed into a paste with an appropriate amount of glacial acetic acid. If necessary, heat it slightly, let it stand for 1h and then filter to convert it into monoammonium salt. After crystal separation, wash with a small amount of glacial acetic acid 1 to 2 times to obtain a pale yellow crude product. Activated carbon was decolorized and recrystallized with 75% ethanol to obtain 15.5 g of white crystals with a yield of 61% and a purity of ≥98%.

The use of monoammonium glycyrrhizinate: it is used in the pharmaceutical industry for cough and phlegm treatment, liver disease treatment, etc.
Related News
  • Properties and Innovative Applications of China Expandable Microspheres

    Properties and Innovative Applications of China Expandable Microspheres

    August 22, 2024Performance Advantages of China Expandable MicrospheresChina expandable microspheres become an ideal lightweight filler and foaming agent for plastics and rubber. Applicable to various materials for p...view
  • Expandable Microspheres Supplier - NCMC

    Expandable Microspheres Supplier - NCMC

    August 18, 2021Expandable microspheres are small, milky white globular plastic particles, 10-45 microns in diameter. When heated to a certain temperature, the volume of foaming agent can be rapidly expanded to dozen...view
  • The Misunderstood "Hero": Bronopol

    The Misunderstood "Hero": Bronopol

    May 17, 2021For a long time, the preservative industry has misunderstood bronopol, thinking that it is a formaldehyde emitter and relies on the release of formaldehyde to achieve a sterilization effect. Due to th...view
  • The Emergency Treatment of Methyl Iodide

    The Emergency Treatment of Methyl Iodide

    October 30, 2020What protective measures should be taken during the use of methyl iodide cas? What should we do if the leakage happens by accident? The answers are as follows: I. The emergency treatment of leakage Ev...view
  • Two Different Types of Anionic Surfactants

    Two Different Types of Anionic Surfactants

    September 24, 2020Anionic surfactant is a kind of product with the longest history, the largest output and the most varieties among surfactants. According to the structure of hydrophilic groups, anionic surfactants can...view
  • Classification of Paraffin

    Classification of Paraffin

    July 20, 2021According to the degree of refining, it can be divided into three types: fully refined paraffin, semi-refined paraffin and crude paraffin. Each type of wax is divided into different varieties accordin...view
  • TEL:+86-25-52337978
  • EMAIL: info@njchm.com
  • ADDRESS:12/F, Block B, Technology and Innovation Building, Nanjing University of Technology, No.5 New Model Road, Nanjing 210009, China