Nanjing Chemical Material Corp.
Service
Products

Production and Function of Monoammonium Glycyrrhizinate Production and Function of Monoammonium Glycyrrhizinate

Table of Content [Hide]
    Monoammonium glycyrrhizinate in China is a chemical substance. This product is mainly used for the treatment of chronic persistent hepatitis, chronic active hepatitis, liver poisoning, and early liver cirrhosis.

    Production method
    It is obtained by using crude glycyrrhizic acid (content about 50%, weight method) as raw material and acidic ethanol as extractant. 50g crude glycyrrhizic acid was added to 170ml of 95% ethanol acidified with hydrochloric acid (Ph value 3.5 ~ 4.0), and stirred and extracted at 40 ~ 50 ℃ for 4h. After filtration, the filter residue was extracted with 100 ml of ethanol under the same conditions for 3 hours. The extracts were combined, and ammonia water or ammonia gas was added dropwise with stirring to make the Ph of the solution 7.2 to 7.5, and allowed to stand at room temperature for 0.5 h to completely precipitate.

    The precipitate is triammonium glycyrrhizinate, which is dispersed into a paste with an appropriate amount of glacial acetic acid. If necessary, heat it slightly, let it stand for 1h and then filter to convert it into monoammonium salt. After crystal separation, wash with a small amount of glacial acetic acid 1 to 2 times to obtain a pale yellow crude product. Activated carbon was decolorized and recrystallized with 75% ethanol to obtain 15.5 g of white crystals with a yield of 61% and a purity of ≥98%.

    The use of monoammonium glycyrrhizinate: it is used in the pharmaceutical industry for cough and phlegm treatment, liver disease treatment, etc.
    References
    Related News
    • Precautions for Using Mixed Methylpyridine

      Precautions for Using Mixed Methylpyridine

      October 26, 20211. About mixed methylpyridineMixed picoline is a member of the compound class of picoline. Picoline is an organic compound containing a pyridine ring substituted by a methyl group at one or more posit...view
    • Uses and Hazards of Bromopropane

      Uses and Hazards of Bromopropane

      June 7, 2022There are still many people who are more sensitive to chemical plants and chemical products. It is true that many chemical substances are lively, flammable, explosive and toxic, but the related produc...view
    • Introduction to DMC Catalyst

      Introduction to DMC Catalyst

      August 25, 2020The DMC catalyst has a freezing point of 4 ℃ and a boiling point of 90 ° C. It is a colorless transparent liquid with a slight aromatic smell at room temperature. It is easy to volatilize and has th...view
    • Commonly Used Amphoteric Surfactants in Detergents

      Commonly Used Amphoteric Surfactants in Detergents

      May 9, 2025In our daily laundry and dishwashing, detergents are our good helpers. However, the components inside that small bottle of detergent contain a lot of knowledge. Today, let's delve into the "l...view
    • Green City, Green Development

      Green City, Green Development

      January 29, 2019June 5th, 2018On the 47th World Environment Day, June 5 th, a large public service activity, "Green City, Green Development" is held in the square of Nanjing Dujiang Victory War Memorial Hall. The the...view
    • By What Means Can Propionyl Chloride be Prepared?

      By What Means Can Propionyl Chloride be Prepared?

      June 4, 2021Propionyl chloride can be prepared by reaction of propionic acid with phosphorus trichloride, phosphorus pentachloride, sulfoxide chloride or phosgene.The following steps and precautions are introduce...view
    • TEL:+86-25-52337978
    • EMAIL: info@njchm.com
    • ADDRESS:12/F, Block B, Technology and Innovation Building, Nanjing University of Technology, No.5 New Model Road, Nanjing 210009, China