Nanjing Chemical Material Corp.

Production and Function of Monoammonium Glycyrrhizinate Production and Function of Monoammonium Glycyrrhizinate

Monoammonium glycyrrhizinate in China is a chemical substance. This product is mainly used for the treatment of chronic persistent hepatitis, chronic active hepatitis, liver poisoning, and early liver cirrhosis.

Production method
It is obtained by using crude glycyrrhizic acid (content about 50%, weight method) as raw material and acidic ethanol as extractant. 50g crude glycyrrhizic acid was added to 170ml of 95% ethanol acidified with hydrochloric acid (Ph value 3.5 ~ 4.0), and stirred and extracted at 40 ~ 50 ℃ for 4h. After filtration, the filter residue was extracted with 100 ml of ethanol under the same conditions for 3 hours. The extracts were combined, and ammonia water or ammonia gas was added dropwise with stirring to make the Ph of the solution 7.2 to 7.5, and allowed to stand at room temperature for 0.5 h to completely precipitate.

The precipitate is triammonium glycyrrhizinate, which is dispersed into a paste with an appropriate amount of glacial acetic acid. If necessary, heat it slightly, let it stand for 1h and then filter to convert it into monoammonium salt. After crystal separation, wash with a small amount of glacial acetic acid 1 to 2 times to obtain a pale yellow crude product. Activated carbon was decolorized and recrystallized with 75% ethanol to obtain 15.5 g of white crystals with a yield of 61% and a purity of ≥98%.

The use of monoammonium glycyrrhizinate: it is used in the pharmaceutical industry for cough and phlegm treatment, liver disease treatment, etc.
Related News
  • Use of Polyether Polyol

    Use of Polyether Polyol

    April 21, 2020Polyether polyol is abbreviated as polyether. It is an oligomer whose main chain contains ether bond (—R—O—R—) and the terminal group or side group contains more than 2 hydroxyl groups (—OH). It ...view
  • Preparation Of Ammonium Iodide​

    Preparation Of Ammonium Iodide​

    August 2, 2019254 g of potassium iodide dissolved in 125 ml of water are mixed with 100 g of ammonium sulfate dissolved in 125 ml of boiling water.view
  • 22th China Coat & SF China 

    22th China Coat & SF China 

    January 31, 2018Nov. 15th-17th , 2017 Shanghai· Shanghai New International Expo Centre CHINACOAT2017 closed its gate successfully at the Shanghai New International Expo Centre (SNIEC), P. R. China. Again, the thre...view
  • Application of 3-Methacryloxypropyltrimethoxysilane

    Application of 3-Methacryloxypropyltrimethoxysilane

    September 24, 20203-Methacryloxypropyltrimethoxysilane is a colorless or light-yellow transparent liquid, soluble in acetone and benzene, but insoluble in water. It is stable at the normal temperature and pressure, and...view
  • Introduction to DMC Catalyst

    Introduction to DMC Catalyst

    August 25, 2020The DMC catalyst has a freezing point of 4 ℃ and a boiling point of 90 ° C. It is a colorless transparent liquid with a slight aromatic smell at room temperature. It is easy to volatilize and has th...view
  • Characteristics of Alpha Olefin Sulfonate

    Characteristics of Alpha Olefin Sulfonate

    July 6, 2020Alpha olefin sulfonate is a formaldehyde-free solution of sodium c14-c16 that preserved by mCi/MI.view
  • TEL:+86-25-52337978
  • EMAIL:
  • ADDRESS:12/F, Block B, Technology and Innovation Building, Nanjing University of Technology, No.5 New Model Road, Nanjing 210009, China