Nanjing Chemical Material Corp.

The Bactericidal and Antiseptic Effect of Bronopol The Bactericidal and Antiseptic Effect of Bronopol

Bronopol is a kind of highly effective and extensive preservative, which has the following obvious advantages:

1. Bronopol at ppm concentration can effectively kill bacteria.

2. It has multiple bactericidal mechanisms, which can kill the common gram-positive bacteria, gram-negative bacteria, yeasts and molds in the environment.

3. It has a special control effect on the common pseudomonas bacteria in water, and it is a powerful supplement to KATHON preservatives.


Since the 1970s, bronopol has been widely used in the antisepsis of washing products. In some cases, bronopol will release a small amount of formaldehyde due to hydrolysis, but the content of formaldehyde released in bronopol is much lower than the dosage required for sterilization. Therefore, bronopol is not a real preservative of "formaldehyde releaser".


Choosing the right detection method is very important to accurately measure the formaldehyde released by bronopol. At present, the acetylacetone spectrophotometric method is widely used in the industry to determine the content of formaldehyde quantatively. This method is based on the selective reaction of formaldehyde with Nash's reagent (acetylacetone) in the presence of ammonium acetate to produce yellow 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine. Then measure the content of formaldehyde according to the spectrophotometry.


Will the trace amount of formaldehyde produced by bronopol due to hydrolysis affect the product safety?


In fact, formaldehyde is present in human bodies and in a large number of common foods. The formaldehyde which is less than 1ppm formed by the hydrolysis of bronopol is lower than the formaldehyde content in these common foods. At the same time, bronopol can be used as a restricted preservative for cosmetics (the dosage should be less than 0.1%, and the formation of nitrosamines should be avoided), which also proves the safety of bronopol in liquid washing products under correct use conditions.

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