Nanjing Chemical Material Corp.
Service
Products

Methyl Iodide Residual Methyl Iodide Residual

Methyl iodide has been highlighted as a potential genotoxic impurity (PGI). A sensitive HS-GC method with ECD was developed and validated for the determination of methyl iodide impurity in Tedizolid phosphate, an active pharmaceutical ingredient. HS-GC method on DB-624,column 60m × 0.53mm, film thickness 3μm, with electron capture detector (ECD) was used. The proposed method was specific, linear, accurate, rugged and precise. The calibration curves showed good linearity over the concentration range of 0.78 μg/g to 11.7 μg/g and the correlation coefficient was 0.997. Method had very low limit of detection (LOD) and limits of quantification (LOQ) are 0.23 μg/g and 0.78 μg/g, respectively, with respect to test concentration. Accuracy was observed within the range 96.0% to 103.2%. This method is a further extended good quality control tool for low level quantitation of methyl iodide impurity in another API, alogliptin benzoate.

Methyl iodide is such a special electrophile, however, that successful alkylations with it cannot usually be used as an indication that alkylations with higher homologs or with more reactive alkylating agents such as allylic or benzylic halides, will necessarily be so rewarding.
Related News
  • 79th API China

    79th API China

    January 31, 2018November 15-17, 2017Xiamen International Convention and Exhibition CenterAPI China is China's leading exhibition for the pharmaceutical manufacturing sector covering the complete spectrum of products ...view
  • What Are the Advantages of DMC Catalyst?

    What Are the Advantages of DMC Catalyst?

    April 21, 2020DMC catalyst is a new type of high-performance catalytic olefin oxide ring-opening polymerization catalyst, suitable for synthesis of olefin oxide polyether containing 1-6 functional groups. DMC catal...view
  • Methyl Iodide Used in Pharmaceuticals

    Methyl Iodide Used in Pharmaceuticals

    April 15, 2020Iodomethane (Methyl iodide) is a colorless liquid. It can be prepared by reacting dimethyl sulfate with concentrated KI.view
  • What is a Wetting Agent

    What is a Wetting Agent

    July 6, 2020A wetting agent is a substance that reduces the surface tension of water, it spreads water on the surface and increases the ability of liquid dispersion.view
  • What is GLycolic Acid?

    What is GLycolic Acid?

    March 13, 2019We like to focus on the ingredients of beauty products. But we prefer to touch the product and explore whether it really works.view
  • 2018 Asia Petrochemical Industry Conference

    2018 Asia Petrochemical Industry Conference

    January 29, 2019August 20-21, 2018 Kuala Lumpur Convention Center MalaysiaAPIC 2018 (Asia Petrochemical Industry Conference, APIC) is making a return to the vibrant city of Kuala Lumpur, Malaysia from 20 - 21 August...view
  • TEL:+86-25-52337978
  • EMAIL: info@njchm.com
  • ADDRESS:12/F, Block B, Technology and Innovation Building, Nanjing University of Technology, No.5 New Model Road, Nanjing 210009, China